abstract：:Mitochondria generate much of the cellular energy through the process of oxidative phosphorylation (OXPHOS). OXPHOS function may be affected by a mutation in any of the mitochondrial (mt) DNA encoded genes and/or nuclear encoded genes that produce proteins imported into the mitochondrion that form (or assemble) the fi...

journal_title：Experimental gerontology

authors： Ballard JW

更新日期：2005-10-01 00:00:00

abstract：:Using data from Germany, we examine if month of birth influences survival up to age 105. Since age reporting at the highest ages is notoriously unreliable we draw on age-validated information from a huge age validation project of 1487 alleged German semi-supercentenarians aged 105+. We use month of birth as an exogeno...

journal_title：Experimental gerontology

authors： Doblhammer G,Scholz R,Maier H

更新日期：2005-10-01 00:00:00

abstract：:Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...

journal_title：Experimental gerontology

authors： Bello RI,Gómez-Díaz C,Burón MI,Alcaín FJ,Navas P,Villalba JM

更新日期：2005-08-01 00:00:00

abstract：:Previous studies have demonstrated that fecundity, like mortality, plateaus at late ages in cohorts of Drosophila melanogaster. Although evolutionary theory can explain the decline and plateau in cohort fecundity at late ages, it is conceivable that lifelong heterogeneity in individual female fecundity is producing th...

journal_title：Experimental gerontology

authors： Rauser CL,Abdel-Aal Y,Shieh JA,Suen CW,Mueller LD,Rose MR

更新日期：2005-08-01 00:00:00

abstract：:The geriatric populations of many countries are growing rapidly and they present major problems to healthcare infrastructures from both medical and economic perspectives. The elderly are predisposed to a variety of diseases, which contribute to a marked increase in morbidity in this subpopulation. The incidence of liv...

journal_title：Experimental gerontology

authors： Schmucker DL

更新日期：2005-08-01 00:00:00

abstract：:MCP-1 and RANTES are molecules that regulate monocyte and T-lymphocyte recruitment towards sites of inflammation. We sought to evaluate the role of these chemokines in Alzheimer's disease (AD), and the effect of acetylcholinesterase inhibitor (AchEI) therapy on their release from peripheral blood mononuclear cells (PB...

journal_title：Experimental gerontology

authors： Iarlori C,Gambi D,Gambi F,Lucci I,Feliciani C,Salvatore M,Reale M

更新日期：2005-07-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：:In aging tissues the oxidative stress increases due to decreased activity of antioxidant enzymes and proteolysis increases due to decreased activity of aminotransferases, which can be modified by hormonal replacement therapy (HRT). The aim of the present study was to determine the effect of HRT on the activities of an...

journal_title：Experimental gerontology

authors： Moorthy K,Sharma D,Basir SF,Baquer NZ

更新日期：2005-04-01 00:00:00

abstract：:The effect of age on brain muscarinic receptor density is unclear. Some in vivo neuroimaging studies have reported a large age-related reduction in muscarinic receptor density; however, others have reported increases or no change. The variability in these results most likely arises because of the heterogeneity of the ...

journal_title：Experimental gerontology

authors： Norbury R,Travis MJ,Erlandsson K,Waddington W,Owens J,Pimlott S,Ell PJ,Murphy DG

更新日期：2005-03-01 00:00:00

abstract：:This study was designed to investigate whether the relationship of fiber size and force is maintained with aging and inactivity. We hypothesized that fiber size and fiber force-generating capacity would decrease in parallel, thus resulting in no change in specific force with either age or inactivity. Thirty male Fisch...

journal_title：Experimental gerontology

authors： Husom AD,Ferrington DA,Thompson LV

更新日期：2005-03-01 00:00:00

abstract：:Heat shock proteins (HSP's) closely interact with 20S proteasome and have been shown to maintain catalytic activity, responsible for the prevention of protein aggregation. A decrease in both proteasome activity and heat shock proteins (HSP's) has been observed with age. We investigated whether life-long calorie restri...

journal_title：Experimental gerontology

authors： Selsby JT,Judge AR,Yimlamai T,Leeuwenburgh C,Dodd SL

更新日期：2005-01-01 00:00:00

abstract：:A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer's amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis. However, poor target spec...

journal_title：Experimental gerontology

authors： Dedeoglu A,Cormier K,Payton S,Tseitlin KA,Kremsky JN,Lai L,Li X,Moir RD,Tanzi RE,Bush AI,Kowall NW,Rogers JT,Huang X

更新日期：2004-11-01 00:00:00

abstract：:Age-related sleep impairments are chronic and common, occurring even in the absence of diagnosable disorders. Additional loss of sleep occurs with clinical sleep disorders, many of which can be ameliorated. This literature, reviewed below, raises the question of the possible biological consequences of age-related, chr...

journal_title：Experimental gerontology

authors： Prinz PN

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on survivals of female HER-2/neu transgenic mice. We propose a semi-parametric model of heterogeneous mortality (frailty m...

journal_title：Experimental gerontology

authors： Semenchenko GV,Anisimov VN,Yashin AI

更新日期：2004-10-01 00:00:00

abstract：:Spatial memory deficits occur earlier in female than male rodents as the animals age, and the cessation of estrous cycle has been suggested to play a role in this phenomenon. We examined the effects of long-term ovariectomy (OVX) and estrogen replacement therapy (ERT) with subcutaneous 17beta-estradiol minipellets on ...

journal_title：Experimental gerontology

authors： Heikkinen T,Puoliväli J,Tanila H

更新日期：2004-09-01 00:00:00

abstract：:The aging process is known to be regulated by specific genes in various organisms, including yeast, the nematode C. elegans, fruitflies and mice. To explore the novel genes involved in aging process, we applied cDNA microarray technology to a replicative senescence model of human dermal fibroblasts (HDF). Eighty-four ...

journal_title：Experimental gerontology

authors： Yoon IK,Kim HK,Kim YK,Song IH,Kim W,Kim S,Baek SH,Kim JH,Kim JR

更新日期：2004-09-01 00:00:00

abstract：:Proteomic analysis is defined as the characterization of the entire set of proteins encoded by a genome. Two-dimensional (2D) electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) are key technologies used in proteomic analysis to gain information about protein...

journal_title：Experimental gerontology

authors： Kim CH,Park DU,Chung AS,Zou Y,Jung KJ,Sung BK,Yu BP,Chung HY

更新日期：2004-08-01 00:00:00

abstract：:The mechanisms responsible for age-associated hearing loss are still incompletely characterized. In this study, we used a murine model of age-dependent hearing loss and evaluated whether this condition is associated with vascular modifications of the structures of the inner ear. We used old C57BL/6J mice that are affe...

journal_title：Experimental gerontology

authors： Picciotti P,Torsello A,Wolf FI,Paludetti G,Gaetani E,Pola R

更新日期：2004-08-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in a wide range of organisms. DR also reduces daily and lifetime fecundity. The latter may be an evolutionary adaptation to survive periods of food shortage. Reproductive rate is often negatively correlated with lifespan, and a reduced cost of reproduction could be the mechani...

journal_title：Experimental gerontology

authors： Mair W,Sgrò CM,Johnson AP,Chapman T,Partridge L

更新日期：2004-07-01 00:00:00

abstract：:Werner's syndrome is a premature aging syndrome with many features common to normal aging. The possible association between phenotypic markers for normal aging and SNP's in the WRN gene was investigated in 426 dizygotic, Danish twins age 70-90 years. All participants were scored every second year using a number of phy...

journal_title：Experimental gerontology

authors： Bendixen MH,Nexø BA,Bohr VA,Frederiksen H,McGue M,Kølvraa S,Christensen K

更新日期：2004-07-01 00:00:00

abstract：:The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent gro...

journal_title：Experimental gerontology

authors： Milgram NW,Head E,Zicker SC,Ikeda-Douglas C,Murphey H,Muggenberg BA,Siwak CT,Tapp PD,Lowry SR,Cotman CW

更新日期：2004-05-01 00:00:00

abstract：:Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...

journal_title：Experimental gerontology

authors： Spremo-Potparevic B,Zivkovic L,Djelic N,Bajic V

更新日期：2004-05-01 00:00:00

abstract：:In the present study we investigated the age-related response of Phytohemaglutinin (PHA)-activated S phase human lymphocytes isolated from peripheral blood from donors of four different age groups, namely young (25-30 years), mid-aged (40-45 years), senior (60-65 years) and elderly (80-95 years) on the induction of th...

journal_title：Experimental gerontology

authors： Kypreou KP,Sourlingas TG,Sekeri-Pataryas KE

更新日期：2004-04-01 00:00:00

abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...

journal_title：Experimental gerontology

authors： Larbi A,Douziech N,Khalil A,Dupuis G,Gheraïri S,Guérard KP,Fülöp T Jr

更新日期：2004-04-01 00:00:00

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer life in mice. However, contradictions in the available data on the biomarkers of aging and predictors of longevity have shown that the research in these fields has...

journal_title：Experimental gerontology

authors： Anisimov VN,Arbeev KG,Popovich IG,Zabezhinksi MA,Rosenfeld SV,Piskunova TS,Arbeeva LS,Semenchenko AV,Yashin AI

更新日期：2004-03-01 00:00:00

abstract：:The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...

journal_title：Experimental gerontology

authors： Simm A,Casselmann C,Schubert A,Hofmann S,Reimann A,Silber RE

更新日期：2004-03-01 00:00:00

abstract：:As recently reported, it is possible to detect and quantify the amount of the deleted human mitochondrial DNA (mtDNA) in whole blood, platelets and peripheral blood mononuclear cells using real-time PCR. The aim of this study was to identify the cell types in human blood carrying the 4977 bp deleted mtDNA and their ac...

journal_title：Experimental gerontology

authors： Mohamed SA,Wesch D,Blumenthal A,Bruse P,Windler K,Ernst M,Kabelitz D,Oehmichen M,Meissner C

更新日期：2004-02-01 00:00:00

abstract：:Chronic low-grade elevations in circulating levels of interleukin (IL)-6 act as a marker of subclinical cardiovascular diseases (CVD) and provide an independent predictor of increased mortality in elderly populations. The purpose of the present study was to test the hypothesis that the IL-6 -174G>C promoter polymorphi...

journal_title：Experimental gerontology

authors： Bruunsgaard H,Christiansen L,Pedersen AN,Schroll M,Jørgensen T,Pedersen BK

更新日期：2004-02-01 00:00:00

abstract：:Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

journal_title：Experimental gerontology

authors： Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

更新日期：2004-01-01 00:00:00

abstract：:Synaptic disturbances may play a key role in the pathophysiology of Alzheimer's disease. To characterize differential synaptic alterations in the brains of Alzheimer patients, chromogranin A, chromogranin B and secretoneurin were applied as soluble constituents for large dense core vesicles, synaptophysin as a vesicle...

journal_title：Experimental gerontology

authors： Lechner T,Adlassnig C,Humpel C,Kaufmann WA,Maier H,Reinstadler-Kramer K,Hinterhölzl J,Mahata SK,Jellinger KA,Marksteiner J

更新日期：2004-01-01 00:00:00

abstract：:Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: A beta and tau pathologies. For AD, and for most neurodegenerative disorde...

journal_title：Experimental gerontology

authors： Delacourte A,Sergeant N,Buée L

更新日期：2003-11-01 00:00:00

abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...

journal_title：Experimental gerontology

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Tsunoda T,Takashima Y

更新日期：2003-10-01 00:00:00

abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...

journal_title：Experimental gerontology

authors： Willems L,Garnham B,Headrick JP

更新日期：2003-10-01 00:00:00

abstract：:Non-insulin dependent diabetes mellitus (NIDDM) has been associated with a number of physiological consequences including neuropathy, retinopathy and incidence of vascular disease. Recently, several authors reviewed studies that suggested that NIDDM is associated with cognitive impairments leading to a higher incidenc...

journal_title：Experimental gerontology

authors： Messier C

更新日期：2003-09-01 00:00:00

abstract：:Replicative senescence appears after a finite number of cell divisions. After proliferation has ceased, senescent cells remain viable for long periods and metabolic modifications are observed such as lipofuscin accumulation. In order to understand this phenomenon, we examined the emergence of subcellular modifications...

journal_title：Experimental gerontology

authors： Gerland LM,Peyrol S,Lallemand C,Branche R,Magaud JP,Ffrench M

更新日期：2003-08-01 00:00:00

abstract：:We have analyzed birth records from the International Species Inventory System database of zoo animals to describe patterns of fertility as a function of age in birds and mammals. Unlike age at death, fertility in captive populations is partly controlled by animal keepers depending on availability of space and potenti...

journal_title：Experimental gerontology

authors： Ricklefs RE,Scheuerlein A,Cohen A

更新日期：2003-07-01 00:00:00

abstract：:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

journal_title：Experimental gerontology

authors： Lutz PL,Prentice HM,Milton SL

更新日期：2003-07-01 00:00:00

abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

journal_title：Experimental gerontology

authors： Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

更新日期：2003-06-01 00:00:00

abstract：:We studied the contractile, histological and biochemical characteristics of regenerating slow (soleus) muscles of aged rats and the effect of IGF-1 treatment on these parameters. Regenerating soleus muscles were studied 21 days after myotoxic injury. In senescent rats (24 month old), the in situ isometric maximal teta...

journal_title：Experimental gerontology

authors： Vignaud A,Noirez P,Besse S,Rieu M,Barritault D,Ferry A

更新日期：2003-05-01 00:00:00